Protein Modification Reagents

eMolecules​ 2523025-40-1 | Tri(Amino-PEG3-amide)-amine | Broadpharm | MFCD28142446 | 755.952 | C33H69N7O12 | 0.000 | NCCOCCOCCOCCC(=O)NCCN(CCNC(=O)CCOCCOCCOCCN)CCNC(=O)CCOCCOCCOCCN | 500mg | 393649487

Tri(Amino-PEG3-amide)-amine | Broadpharm | 2523025-40-1 | MFCD28142446 | 755.952 | C33H69N7O12 | 0.000 | NCCOCCOCCOCCC(=O)NCCN(CCNC(=O)CCOCCOCCOCCN)CCNC(=O)CCOCCOCCOCCN | 500mg | 393649487

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Medchemexpress LLC PTDA-PEG4-azide | 2639395-40-5 | 99.3% | 539.54 | C22H33N7O9 | 5 MG

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PTDA-PEG4-azide is a PEG4-linked azide reagent used as an ADC linker and for click-chemistry bioconjugation in research applications. The compound is supplied as a white to off-white oil with high purity and is provided in small, research-scale quantities.

• High purity (99.3%).
• Molecular weight 539.54 g/mol.
• Molecular formula C22H33N7O9.
• Soluble in DMSO at 125 mg/mL; ultrasonic assistance recommended; use freshly opened DMSO.
• Storage: pure form -20°C (stable for 3 years); in solvent -80°C (6 months), -20°C (1 month).
• Available in small pack sizes suitable for research use.

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Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG

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Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research. It features an NHS-activated ester for amine coupling and an aldehyde-phenyl functional handle for orthogonal conjugation chemistry.

• Provides a noncleavable 2-unit PEG spacer for conjugation
• NHS ester activated for efficient coupling to primary amines
• Aldehyde-phenyl functional group for orthogonal conjugation chemistry
• High purity suitable for research applications
• Available in multiple pack sizes and formats, including 100 MG

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Nanocs Palmitic acid PEG, mPEG-PLA, Specification: 5000 Da,100 mg

Palmitic acid is a 16 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified palmitic acid is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptide

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Medchemexpress LLC HS-PEG3-CH2CH2NH2 hydrochloride | 2863676-86-0 | 95.0% | 100 MG

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HS-PEG3-CH2CH2NH2 hydrochloride is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• PROTACs utilize two distinct ligands connected by a linker
• Selectively degrades target proteins through the ubiquitin-proteasome system

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Medchemexpress LLC Mal-PEG4-propargyl | 1262681-30-0 | MFCD29041878 | 99.7% | C15H21NO6 | 10MG

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Mal-PEG4-propargyl is a bifunctional PEG4 linker bearing a maleimide and a propargyl (alkyne) group. It is designed for use in bioconjugation and linker assembly, enabling thiol-maleimide coupling and copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach diverse ligands or linkers.

• Maleimide group enables rapid, selective thiol conjugation.
• Propargyl (alkyne) group supports CuAAC "click" reactions.
• PEG4 spacer improves solubility and reduces steric hindrance.
• Low molecular weight (311.33 g·mol⁻¹) for minimal steric impact.
• High supplied purity (99.7%) for reliable synthetic performance.

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Medchemexpress LLC BCN-PEG3-biotin | 1263166-92-2 | 95.0% | 594.76 | C29H46N4O7S | 100 MG

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BCN-PEG3-biotin is a click-chemistry linker containing a bicyclononyne (BCN) group, a three-unit polyethylene glycol spacer, and a terminal biotin. It is used for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules and as a biotin tag for affinity capture or detection.

• Facilitates copper-free SPAAC click reactions.
• Three-unit PEG spacer improves solubility and reduces steric hindrance.
• Terminal biotin enables streptavidin-based capture and detection.
• Supplied as an off-white to light yellow solid with ≥95.0% purity.
• Soluble in DMSO (100 mg/mL); powder storage recommended at -20°C.

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eMolecules​ DSPE-Amide-PEG-Rhodamine, MW 2,000 | Broadpharm |1376.220 | C75H121ClN4NaO13P | 97.000 | [Na+].[Cl-].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)COCCOCCNC(=O)c1ccccc1-c1c2ccc(cc2oc2cc(ccc12)=[N+](CC)CC)N(CC)CC)OC(=O)CCCCCCCCCCCCCCCCC | 5mg | 795361903

DSPE-Amide-PEG-Rhodamine, MW 2,000 | Broadpharm |1376.220 | C75H121ClN4NaO13P | 97.000 | [Na+].[Cl-].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)COCCOCCNC(=O)c1ccccc1-c1c2ccc(cc2oc2cc(ccc12)=[N+](CC)CC)N(CC)CC)OC(=O)CCCCCCCCCCCCCCCCC | 5mg | 795361903

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eMolecules​ 882518-89-0 | Tos-PEG3-CH2CO2tBu | Broadpharm | MFCD27977515 | 374.450 | C17H26O7S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCC(=O)OC(C)(C)C | 250mg | 229582215

Tos-PEG3-CH2CO2tBu | Broadpharm | 882518-89-0 | MFCD27977515 | 374.450 | C17H26O7S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCC(=O)OC(C)(C)C | 250mg | 229582215

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eMolecules​ 2226235-96-5 | N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 | Broadpharm724.340 | C39H54ClN5O6 | 97.000 | [Cl-].CC1(C)\C(=C/C=C/C=C/C2=[N+](CCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)N(CCOCCOCCO)c2ccccc12 | 10mg | 298819354

N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 | Broadpharm | 2226235-96-5724.340 | C39H54ClN5O6 | 97.000 | [Cl-].CC1(C)\C(=C/C=C/C=C/C2=[N+](CCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)N(CCOCCOCCO)c2ccccc12 | 10mg | 298819354

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eMolecules​ 106492-60-8 | Aminooxy-PEG4-alcohol | Broadpharm | MFCD30828691 | 209.242 | C8H19NO5 | 98.000 | NOCCOCCOCCOCCO | 500mg | 349512554

Aminooxy-PEG4-alcohol | Broadpharm | 106492-60-8 | MFCD30828691 | 209.242 | C8H19NO5 | 98.000 | NOCCOCCOCCOCCO | 500mg | 349512554

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Broadpharm Fmoc-N-Amido-PEG8-Acid, 5 g, CAS 756526-02-0, Solid or viscous liquid, 98% purity, Linear, dPEG spacer, 8 PEG units

Fmoc-N-Amido-PEG8-Acid is a versatile heterobifunctional polyethylene glycol (PEG) linker specifically designed for applications in bioconjugation, including peptide synthesis and Antibody-Drug Conjugates (ADCs). This product features a unique Fmoc-protected amine and a terminal carboxylic acid, offering two anchor points for modifications. The hydrophilic PEG8 spacer enhances solubility in aqueous media, improving the pharmacokinetic properties of peptides and extending their circulation times in vivo.

• Designed for versatile modifications with two distinct functional groups.
• Improves water solubility and expands hydrodynamic volume.
• Reduces renal clearance and protects peptides from proteolysis.
• Facilitates stable amide bond formation with primary amines using activators.
• Stable under -20°C storage conditions.
• Shipping is done at ambient temperature.

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Broadpharm DBCO-PEG8-VAL-CIT-PAB-PNP250MG

DBCO-PEG8-Val-Cit-PAB-PNP, 250mg

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Broadpharm Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | MFCD28334559 | 25mg

Methyltetrazine-PEG5-NHS ester | Purity: 95% | MW: 533.5 | 1802907-92-1 | MFCD28334559 | 25mg

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Medchemexpress LLC Bis-PEG4-TFP ester | 1446282-42-3 | 98.0% | 590.41 g/mol | C24H22F8O8 | 50 MG

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Bis-PEG4-TFP ester is a PEG-based PROTAC linker with two tetrafluorophenyl (TFP) activated ester groups that enable facile conjugation to amine-containing ligands. It is provided as a high-purity research reagent intended for use in synthesis of bifunctional molecules and linker optimization.

• Contains two TFP-activated ester termini for rapid amide formation.
• Provides a PEG4 spacer to improve solubility and molecular flexibility.
• Enables efficient coupling to primary amines under mild conditions.
• High purity suitable for research and synthetic workflows.
• Available in small pack sizes convenient for laboratory use.

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